Treatment of primary hypercholesterolemia (type IIa & IIb hyperlipoproteinemia) caused by elevated LDL cholesterol conc in patients unresponsive to diet or non-drug measures. Reduction of elevated LDL in patients w/ combined hypercholesterolemia & hypertriglyceridemia.
Adult Initial: 20 mg once daily. Adjust dose at 4 wk intervals. Maintenance: 20-80 mg daily. Patients on immunosuppressive therapy should be given ≤20 mg daily.
Persistent elevation of serum transaminases up to 3 times the normal values (discontinue). Perform baseline & periodic liver function tests; & baseline serum creatine kinase levels. Chronic or substantial alcohol consumption or history of liver disease. Women of childbearing potential.
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