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As phenytoin, barbiturates, ephedrine and rifampicin may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and reduced physiological activity, the dosage may have to be adjusted.
These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs.
The prothrombin time should be checked frequently in patients who are receiving corticosteroids and coumarin anticoagulants at the same time.
When corticosteroids are administered concomitantly with potassium - depleting diuretics, patients should be observed closely for development of hypokalaemia.
