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Hydralazine HCl should not be used during the first trimester of pregnancy unless the potential benefits outweigh the possible risks.
Animal studies indicate that high doses of hydralazine are teratogenic in mice, possibly in rabbits, but not in rats. Although clinical experience does not include any positive evidence of adverse effects on the human fetus, hydralazine should be used during pregnancy only if the benefit clearly justifies the potential risk to the fetus. Hydralazine is excreted in human breast milk.
