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When hydralazine is administered with diuretics or other antihypertensive agents, the hypotensive effect of hydralazine may be increased. This effect is usually used to therapeutic advantage, but careful adjustment of dosage is necessary when these drugs are used concomitantly. Monoamine oxidase (MAO) inhibitors should be used with caution in patients receiving hydralazine since these drugs have a synergistic effect resulting in a marked decrease in blood pressure. Hydralazine may reduce the pressor response to epinephrine.
Indomethacin does not attenuate the effects of hydralazine in normal subjects, and thus does not support the hypothesis that endogenous prostaglandins are involved in the mechanism of action of hydralazine.
