Pharmacology: Chloramphenicol binds specifically to the 50S subunit of 70S ribosomes, preventing its movement along messenger RNA, which occurs in the early stages of protein synthesis. It inhibits peptide bond formation presumably due to direct inhibition of peptide transferase or prevention of attachment of AA-TRNA to the 50S subunit. Inhibition of mitochondrial respiratory chain. Its antimicrobial and toxic effects may be explained by all of these mechanisms.
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