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Chloramphenicol is inactivated in the liver and may therefore interact with drugs which are metabolized by hepatic microsomal enzymes. Chloramphenicol enhances the effects of coumarin anticoagulants, some hypoglycemic agents and antiepileptics. The half life of chloramphenicol may be affected by paracetamol, phenobarbitone, phenytoin or rifampicin.
Chloramphenicol can give disulfiram-like reaction with alcohol.
