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Capsule: Monitoring of patients taking diazepam, warfarin, and phenytoin concomitantly with OMEPAC 20 is recommended to determine whether it is necessary to adjust the dosage of these drugs. OMEPAC 20 may interfere with the metabolism of drugs metabolised by cytochrome 450 enzyme system. No interaction with concomitantly administered antacids has been found.
Injection: Omeprazole is metabolized by the cytochrome P450 system primarily by isoenzyme CYP2C19, and may alter the metabolism of some other drugs metabolized by these enzymes. Omeprazole may prolong the elimination of diazepam, phenytoin, and warfarin. Omeprazole can reduce the absorption of drugs such as ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH.
