Aceclofenac: Management of acute poisoning with nonsteroidal anti-inflammatory drugs (NSAIDs) essentially consists of supportive and symptomatic measures. There is no human data available on the consequences of aceclofenac overdosage. The therapeutic measures to be taken are: Absorption should be prevented as soon as possible after overdosage by means of gastric lavage and treatment with activated charcoal; supportive and symptomatic treatment should be given for complications eg, hypotension, renal failure, convulsions, gastrointestinal irritation, an respiratory depression; specific therapies eg, forced diuresis, dialysis or haemoperfusion are probably of no help in eliminating NSAIDs due to their high rate of protein binding and extensive metabolism.
Rabeprazole: Experience to date with deliberate or accidental overdose is limited. The maximum established exposure has not exceeded 60 mg twice daily or 160 mg once daily. Effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention. No specific antidote is known. Rabeprazole sodium is extensively protein-bound and is therefore, not dialysable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilized.