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Indications and Dosage
Intramuscular, Intravenous
Cerebrovascular disorders, Cognitive disorder, Head injury, Parkinson's disease Adult: 500-1,000 mg daily given via IM inj or slow IV inj over 3-5 minutes, or infused at a rate of 40-60 drops/minute. Oral Cerebrovascular disorders, Cognitive disorder, Head injury, Parkinson's disease Adult: As tab: 500 mg once daily or bid, or 1,000 mg once daily. As solution: 100-200 mg bid or tid.
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Administration
May be taken with or without food.
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Incompatibility
Incompatible with meclofenoxate-containing products.
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Contraindications
Hypertonia of the parasympathetic nervous system.
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Special Precautions
Patients with persistent intracranial haemorrhage. Pregnancy and lactation.
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Adverse Reactions
Cardiac disorders: Bradycardia, tachycardia.
Gastrointestinal disorders: Diarrhoea, epigastric discomfort, stomach pain. General disorders and admin site conditions: Fatigue. Nervous system disorders: Dizziness, headache. Skin and subcutaneous tissue disorders: Rashes. Vascular disorders: Hypotension. |
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Drug Interactions
May potentiate the effect of levodopa.
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Action
Description: Citicoline is a naturally occurring endogenous nucleoside involved in the biosynthesis of lecithin. It increases the synthesis of phosphatidylcholine (main neuronal membrane phospholipid) and enhances acetylcholine production. It is also claimed that it increases blood flow and oxygen consumption in the brain.
Synonym: CDP-choline, cytidine diphosphate. Pharmacokinetics: Absorption: Rapidly absorbed in the gastrointestinal tract. Bioavailability: >90%. Time to peak plasma concentration: 1 hour after oral administration followed by 2nd peak at 24 hours post-dosing. Distribution: Distributed throughout the body, crosses blood-brain barrier. Metabolism: Metabolised in the liver and gut wall via hydrolysis to choline and cytidine. Excretion: Mainly via respiratory CO2 and urine. Elimination half-life: 71 hours (urine); 56 hours (respiratory CO2). |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Citicoline, CID=13804, https://pubchem.ncbi.nlm.nih.gov/compound/Citicoline (accessed on Jan. 21, 2020) |
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Storage
Store below 30°C.
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MIMS Class
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ATC Classification
N06BX06 - citicoline ; Belongs to the class of other psychostimulants and nootropics.
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References
Anon. Citicoline. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/02/2019. Buckingham R (ed). Citicoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/02/2019. Cholinerv (UNILAB, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 30/01/2019 .
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