Zyvox Drug Interactions

Linezolid is a weak, reversible, nonselective inhibitor of monoamine oxidase. Therefore, some patients receiving linezolid may experience a mild reversible enhancement on the pressor response induced by pseudoephedrine HCl or phenylpropanolamine HCl. Initial doses of adrenergic agents, such as dopamine or dopamine agonists, should be reduced and titrated to achieve the desired response.
Very rare spontaneous reports of serotonin syndrome with co-administration of linezolid and serotonergic agents have been reported (see Precautions).
Antibiotics: The pharmacokinetics of linezolid were not altered when administered together with either aztreonam or gentamicin. The effect of rifampin on the pharmacokinetics of linezolid was studied in sixteen healthy adult male volunteers administered linezolid 600 mg twice daily for 2.5 days with and without rifampin 600 mg once daily for 8 days. Rifampin decreased the linezolid C_max and AUC by a mean 21% [90% CI, 15, 27] and a mean 32% [90% CI, 27, 37], respectively. The mechanism of this interaction and its clinical significance are unknown (see Precautions).