Zyvox Caution For Usage

Incompatibilities: Solution for Infusion: Linezolid solution for infusion was physically incompatible with the following drugs when combined in simulated Y-site administration: amphotericin B, chlorpromazine HCl, diazepam, pentamidine isothionate, phenytoin sodium, erythromycin lactobionate, and trimethoprim-sulfamethoxazole.
Linezolid solution for infusion was chemically incompatible when combined with ceftriaxone sodium.
Special precautions for disposal and other handling: Solution for Infusion Administration: Linezolid solution for infusion is supplied in single-use, ready-to-use infusion bags. Parenteral drug products should be inspected visually for particulate matter prior to administration. Check for minute leaks by firmly squeezing the bag. If leaks are detected, discard the solution, as sterility may be impaired.
Linezolid solution for infusion should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections. Additives should not be introduced into this solution. If linezolid solution for infusion is to be given concomitantly with another drug, each drug should be given separately in accordance with the recommended dosage and route of administration for each product. In particular, physical incompatibilities resulted when linezolid solution for infusion was combined with the following drugs during simulated Y-site administration: amphotericin B, chlorpromazine HCl, diazepam, pentamidine isothionate, erythromycin lactobionate, phenytoin sodium, and trimethoprim-sulfamethoxazole. Additionally, chemical incompatibility resulted when linezolid solution for infusion was combined with ceftriaxone sodium.
If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of linezolid solution for infusion with an infusion solution compatible with linezolid solution for infusion and with any other drug(s) administered via this common line.
Compatible Intravenous Solutions: 5% Dextrose Injection, USP; 0.9% Sodium Chloride Injection, USP; Lactated Ringer's Injection, USP.
Keep the infusion bags in the overwrap until ready to use. Store at room temperature. Protect from freezing. Linezolid solution for infusion may exhibit a yellow color that can intensify over time without adversely affecting potency.