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Click on icon to see table/diagram/imageDosage in paediatric patients with creatinine clearance (CrCL) >50 mL/min/1.73 m2: Table 2 shows the recommended intravenous doses for paediatric patients with estimated creatinine clearance (CrCL) >50 mL/min/1.73 m2 (see Precautions and Pharmacology: Pharmacodynamics under Actions). (See Table 12.)
Click on icon to see table/diagram/imageSpecial populations: Elderly: No dosage adjustment is required in elderly patients (see Pharmacology: Pharmacokinetics under Actions).
Renal impairment: No dosage adjustment is required in patients with mild renal impairment (estimated CrCL >50 - ≤80 mL/min) (see Pharmacology: Pharmacokinetics under Actions).
Table 13 shows the recommended dose adjustments for adults with estimated CrCL ≤50 mL/min (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Dosage in adults with creatinine clearance (CrCL) ≤50 mL/min: (See Table 13.)
Click on icon to see table/diagram/imageTable 14 and Table 15 shows the recommended dose adjustments for paediatric patients with estimated CrCL ≤50 mL/min/1.73 m2 according to different age groups (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Dosage in paediatric patients 2 years of age with CrCl50 mL/min/1.73 m2: (See Table 14.)
Click on icon to see table/diagram/imageDosage in paediatric patients <2 years of age with CrCl 50 mL/min/1.73 m2: (See Table 15.)
Click on icon to see table/diagram/imageThere is insufficient information to recommend a dosage regimen for paediatric patients <2 years of age that have a CrCL <16 mL/min/1.73 m2.
Hepatic impairment: No dosage adjustment is required in patients with hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
Paediatric patients: The safety and efficacy in paediatric patients <3 months old have not been established. No data are available.
Method of administration: Intravenous use.
Zavicefta is administered by intravenous infusion over 120 minutes in an appropriate infusion volume (see Instructions for use, handling and disposal under Cautions for Usage).
For instructions on reconstitution and dilution of the medicinal product before administration, (see Instructions for use, handling and disposal under Cautions for Usage).
