Adult cIAI 1 vial every 8 hr over 2 hr for 5-14 days.
cUTI including pyelonephritis 1 vial every 8 hr over 2 hr for 5-10 days, may be increased up to 14 days if w/ bacteraemia.
HAP including VAP 1 vial every 8 hr over 2 hr for 7-14 days.
Bacteraemia associated w/ or suspected to be associated w/ cIAI, cUTI, HAP including VAP 1 vial every 8 hr over 2 hr. Duration: In accordance w/ infection site.
Renal impairment CrCl 31-50 mL/min 1,000 mg/250 mg every 8 hr over 2 hr,
16-30 mL/min 750 mg/187.5 mg every 12 hr over 2 hr,
6-15 mL/min 750 mg/187.5 mg every 24 hr over 2 hr,
ESRD including on haemodialysis 750 mg/187.5 mg every 48 hr over 2 hr.
Childn 6 mth to <18 yr cIAI, cUTI including pyelonephritis 50 mg/12.5 mg/kg every 8 hr over 2 hr for 5-14 days. Max: 2,000 mg/500 mg,
3-6 mth 40 mg/10 mg/kg every 8 hr over 2 hr for 5-14 days.
Renal impairment Childn 2 to <18 yr, CrCL 31-50 mL/min 25 mg/6.25 mg/kg every 8 hr over 2 hr to max: 1,000 mg/250 mg,
16-30 mL/min 18.75 mg/4.7 mg/kg every 12 hr over 2 hr to max: 750 mg/187.5 mg,
6-15 mL/min 18.75 mg/4.7 mg/kg every 24 hr over 2 hr to max: 750 mg/187.5 mg.
ESRD including on haemodialysis 18.75 mg/4.7 mg/kg every 48 hr over 2 hr to max: 750 mg/187.5 mg.
Childn w/ renal impairment 31-50 mL/min, 3 to <6 mth 20 mg/5 mg/kg every 8 hr over 2 hr,
6 mth to <2 yr 25 mg/6.25 mg/kg every 8 hr over 2 hr,
16-30 mL/min, 3 to < 6 mth 15 mg/3.75 mg/kg every 12 hr over 2,
6 mth to < 2 yr 18.75 mg/4.7 mg/kg every 12 hr over 2 hr.
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