Veloxin Mechanism of Action

Pharmacology: Meclozine is a piperazine derivative with the properties of antihistamines. It has Central Nervous System (CNS) depressant, anticholinergic, antiemetic, antispasmodic, and local anesthetic effects in addition to antihistaminic activity. The drug depresses labyrinth excitability and conduction in vestibular-cerebellar pathways. The antiemetic and antimotion-sickness actions of Meclozine result, at least in part, from its central anticholinergic and CNS depressant properties.
The onset of action of Meclozine is about 1 hour and the drug has prolonged duration of action, with effects persisting 8 to 24 hours following administration of a single oral dose. The drug has a plasma half-life of 6 hours. The metabolic rate of Meclozine in humans is unknown. In rats, Meclozine is metabolized (probably in the liver) to norchlorcyclizine. This metabolite is distributed throughout most body tissues and crosses the placenta. The drug is excreted in faeces unchanged and in urine as norchlorcyclizine.
Pyridoxine is a water-soluble, B complex vitamin. It has been used for the management of vertigo, motion sickness, depression associated with pregnancy.
Pyridoxine is readily absorbed from the gastrointestinal (GI) tract after oral doses and is converted to the active forms pyridoxal phosphate and pyridoxamine phosphate. They are stored mainly in the liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites which are excreted in the urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.