Veloxin Drug Interactions

Meclozine has an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). It may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. In addition, the additive CNS depression may occur when Meclozine is administered concomitantly with other CNS depressants including barbiturates, tranquilizers, and alcohol. If Meclozine is used concomitantly with other depressant drugs, caution should be used to avoid overdosage.
Pyridoxine reduces the effects of levodopa, but this does not occur if a dopa decarboxylase inhibitor is also given. Pyridoxine reduces the activity of altretamine. It has also been reported to decrease serum concentrations of phenobarbital and phenytoin. Some drugs may increase the requirements for Pyridoxine; such drugs include hydralazine, isoniazid, penicillamine, and oral contraceptives.