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Pregnancy: It is preferable to avoid the use of TRACIDOL during the first trimester of pregnancy. From the second trimester, cautious use is possible, punctually.
In human, there are no sufficient data to assess malformative effect of tramadol when given during first trimester of pregnancy. Animal studies did not show any teratogenic effects, but at high doses, foetotoxicity due to maternotoxicity appeared.
As other opioid analgesics: During the first trimester, chronic use of tramadol may induce-for any dosage-a withdrawal syndrome in the newborn. At the end of pregnancy, high dosages-even for short term treatment-may induce respiratory depression in the newborn.
Lactation: About 0.1% of maternal dose of tramadol is excreted into milk. Punctual administration appears to be safe for the newborn. If repeated administration for several days is necessary, breast-feeding should be discontinued.
If long-term treatment after birth is necessary, breast-feeding is contraindicated.
