Sign Out
Tramadol should be used with caution in opioid-dependent patients, or in patients with cranial trauma, in patients prone to convulsive disorder, biliary tract disorders, in a state of shock, in an altered state of consciousness for unknown reasons, with problem affecting the respiratory center or the respiratory function, or with an increased intracranial pressure.
At therapeutic doses, tramadol has the potential to cause withdrawal symptoms. Tramadol has a low dependence potential. On long-term use tolerance, psychic and physical dependence may develop. In patients with a tendency to drug abuse or dependence, treatment should be for short periods under strict medical supervision.
Symptoms of withdrawal reactions, similar to those during opiate withdrawal may occur as follows: agitation, anxiety, nervousness, insomnia, hyperkinesia, tremor and gastrointestinal symptoms.
At recommended doses tramadol is unlikely to produce clinically relevant respiratory depression. Care should however be taken when administering tramadol to patients with existing respiratory depression or excessive bronchial secretion and in those patients taking concomitant CNS depressant drugs.
Effects on Ability to Drive and Use Machines: Tramadol may cause drowsiness. Alcohol and other medicinal products, which depress the central nervous system, may increase this effect. If affected, the patient should not drive or operate machinery.
