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Symptoms: Also for other opioid analgesics the typical symptoms of overdose are miosis, emesis, cardiovascular collapse, sedation and coma, seizures and respiratory depression.
Treatment: Supportive action should be taken: the respiratory tract should be kept open and the cardiovascular functions should be supported. In case of respiratory depression naloxone may be used in resuscitation. The convulsions can be controlled with diazepam.
Tramadol is minimally eliminated from the serum via haemodialysis or blood filtering. For this reason it is not sufficient to perform only haemodialysis or blood filtering for the treatment of acute Tramadol intoxication.
The removal of the unabsorbed drug by gastric emptying is useful; particularly when a modified release formulation has been taken.
