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Concurrent administration of probenecid and piperacillin/tazobactam produced a longer half-life and lower renal clearance for both piperacillin and tazobactam.
Whenever this product is used with another antibiotic, especially aminoglycoside, the drug must not be mixed in intravenous solutions or administered concurrently due to physical incompatibility.
During simultaneous administration of high doses of heparin, oral anticoagulants and other drugs which may affect the blood coagulation system and/or the thrombocyte function, the coagulation parameters should be tested more frequently and monitored regularly.
Piperacillin has been reported to prolong the action of vecuronium. Caution should be exercised when used perioperatively with vecuronium and similar neuromuscular-blocking agents.
Penicillin may reduce the excretion of methotrexate. Serum level of methotrexate should be monitored in patients on high-dose methotrexate therapy.
