Tapicin Dosage/Direction for Use

Adults and children >12 years with normal renal function: Usual dosage: 4.5 g every 8 hours.
The total daily dosage depends on the severity and localization of the infection and can vary from 2.25-4.5 g administered every 6 or 8 hours.
Neutropenia: Recommended dose: 4.5 g every 6 hours in combination with aminoglycoside.
Neutropenic patients with signs of infection (eg. Fever) should receive immediately empirical antibiotic therapy before laboratory results are available.
Children: <12 years: This product is only recommended for the treatment of children with neutropenia.
Children weighing >50 kg: Follow adult dosing guideline. Including the aminoglycoside.
Children with normal renal function and weighing <50 kg: Adjust the dose to 90 mg/kg (80 mg piperacillin/10 mg tazobactam) administered every 6 hours in combination with an aminoglycoside.
Elderly: This product may be used at the same dose levels as adults except in cases of renal impairment.
Renal insufficiency: Adults and children weighing >50 kg: The IV dose should be adjusted to the degree of actual renal impairment. The suggested daily doses are as follows: (See Table 1.)

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Patients on haemodialysis: The maximum daily dose is 8 g/1 g. Because haemodialysis removes 30-50% of piperacillin in 4 hours, 1 additional dose of 2 g/250 mg should be administered following each dialysis period.
Patients with renal failure and hepatic insufficiency: Measurement of serum levels of Piperacillin/Tazobactam will provide additional guidance for adjusting dosage.
Adults and children weighing <50 kg: The IV dosage should be adjusted to the degree of actual renal impairment as follows: (See Table 2.)

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Children <50 kg on haemodialysis: The recommended dose is 45 mg/kg every 8 hours. Each patient must be monitored closely and dosage regimen to be adjusted accordingly.
Duration of therapy: Therapy is recommended to be a minimum of 5 days and maximum of 14 days, considering that dose administration should continue at least 48 hours after the resolution of clinical signs and symptoms or fever.
Mode of Administration: This product may be given by slow IV injection (3-5 minutes) or by infusion (20-30 minutes).
Reconstitution: IV Injection: Each vial of 4.5 g or 2.25 g should be reconstituted with 20 ml or 10 ml of one of the reconstitution diluent respectively. Swirl until dissolved.
IV infusion: Each vial should be reconstituted with at least 20 ml of one of the reconstitution diluents. The reconstituted solution should be further diluted to the desired volume (50-150 ml) with one of the reconstitution diluents.
Reconstitution diluents: Water for injection (max volume used for each dose is 50 ml), 5% Dextrose injection, 0.9% Sodium Chloride injection.
This product does not contain preservative, therefore appropriate aseptic technique should be performed during preparation. Use the reconstituted solution immediately after preparation.