Tapicin Adverse Reactions

Rarely, significant leucopenia may be associated with prolonged therapy. Very rarely, interstitial nephritis may occur.
Hepatitis and cholestatic jaundice have been reported rarely with some penicillins and β-lactamase inhibitors.
Haemolytic anemia has been reported rarely with penicillin and piperacillin/tazobactam.
Adverse local reactions that were reported were plebitis and thrombophlebitis.
Systemic adverse clinical reactions reported were diarrhea, rash, erythema, pruritus, vomiting, allergic reactions, nausea, urticaria, superinfections, skin reactions, eruption, increased sweating, erythema, multiforme, eczema, exanthema, maculopapular rash, soft/loose stools, stomatitis, constipation, muscular weakness, hallucination, dry mouth, hypotension, muscle pain, superficial phlebitis, fever, hot flushes, oedema, tiredness.
Local reactions included injection site inflammation and injection site pain when solution was not prepared according to the recommendation.
Adverse laboratory changes without regard to drug relationship that were reported were transient reduction in the white blood cell count (leucopenia), eosinophilia, thrombocytosis, thrombocytopenia, positive Coombs' test, hypokalemia, transient rise in the serum levels of liver enzymes, bilirubin and increased level of renal function parameters have been detected in serum.