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Hylan G-F 20 is biologically similar to hyaluronan. Hyaluronan is a component of synovial fluid which is responsible for its elastoviscosity. The mechanical (elastoviscous) properties of hylan G-F 20 are, however, superior to those of synovial fluid and hyaluronan solutions of comparable concentration. Hylan G-F 20 has an elasticity (storage modulus G') at 2.5 Hz of 111 ± 13 Pascals (Pa) and a viscosity (loss modulus G") of 25 ± 2 Pa. Elasticity and viscosity of knee synovial fluid of 18- to 27-year-old humans measured with comparable method at 2.5 Hz are G' = 117 ± 13 Pa and G" = 45 ± 8 Pa. Hylans are degraded in the body by the same pathway as hyaluronan, and breakdown products are nontoxic.
