Synvisc/Synvisc-One Caution For Usage

Do not use hylan G-F 20 if package is opened or damaged.
The contents of the syringe must be used immediately after its packaging is opened.
Remove synovial fluid or effusion before injecting hylan G-F 20.
Inject at room temperature.
To remove the syringe from the blister (or tray), take hold of it by the body, without touching the plunger rod.
Administer using strict aseptic procedures, taking particular care when removing the tip cap.
Twist the tip cap before pulling it off, as this will minimise product leakage.
Use an appropriate size of needle: 18 to 22 gauge; Depending on the joint to be treated use the appropriate length of needle.
To ensure a tight seal and prevent leakage during administration secure the needle tightly while firmly holding the Luer hub.
Do not tighten or apply excessive leverage when attaching the needle or removing the needle guard, as this may break the tip of the syringe.
Inject into the synovial space only, using if necessary, appropriate guidance such as fluoroscopy especially in joints such as the hip and shoulder.
The syringe contents are for single use only. The recommended dosage guidelines state to inject the full volume (2 mL for Synvisc; 6 mL for Synvisc-One) of the syringe. Discard any unused Synvisc/Synvisc-One.
Do not re-use the syringe and/or needle. Re-use of syringes, needles and/or product from a used syringe may result in loss of sterility, product contamination and/or incomplete treatment.
When using fluoroscopic guidance, ionic or non-ionic contrast agent may be utilized. No more than 1 ml of contrast agent should be used per 2 ml of hylan G-F 20.
Do not resterilise hylan G-F 20.