Sign Out
Symptoms and Treatment of Overdose: Antihistamine overdosage reactions may vary from CNS depression to stimulation. Atropine-like signs and symptoms such as dry mouth; fixed, dilated pupils; flushing and gastrointestinal symptoms may also occur.
If vomiting has not occurred spontaneously, the patient should be induced to vomit. Precautions against aspiration must be taken especially in infants and children. If vomiting is unsuccessful, gastric lavage is indicated within 3 hours of ingestion and even later if large amounts of milk or cream has been given beforehand.
Isotonic or ½ isotonic saline is the lavage solution of choice. Vasopressors may be used to treat hypotension.
