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Administration of dextromethorphan to patients receiving MAO inhibitors may produce severe reactions; hyperpyrexia and fatalities have been reported.
Antihistamine may enhance the sedative effects of CNS depressants.
MAO inhibitors may enhance the antimuscarinic effects of antihistamines, and antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and tricyclic antidepressants.
