Stablon Dosage/Direction for Use

Posology: The recommended dosage is one tablet containing 12.5 mg, three times a day (morning, midday and evening) at the beginning of the main meals.
Special populations: Elderly subjects: The efficacy and safety of tianeptine have been established in elderly depressed patients (≥ 65 years) (see Pharmacology: Pharmacodynamics under Actions). No dose adjustment is required in relation to age.
In frail elderly patients (< 55 kg), the dosage should be restricted to 2 tablets per day (see Pharmacology: Pharmacokinetics under Actions).
Renal failure: In patients with severe renal failure (ClCr < 19 ml/min), the posology should be restricted to 2 tablets per day (see Pharmacology: Pharmacokinetics under Actions).
Hepatic impairment: In patients with severe cirrhosis (Class C, Child Pugh Score), the posology should be restricted to 2 tablets per day (see Pharmacology: Pharmacokinetics under Actions).
In chronic alcoholic patients, irrespective of whether they have mild or moderate cirrhosis or no cirrhosis, the posology does not need to be adjusted (see Pharmacology: Pharmacokinetics under Actions).
Paediatric population: The safety and efficacy of tianeptine in children and adolescents under 18 years of age have not been determined. There is no data available (see Precautions).
Tianeptine is contraindicated in children and adolescents under 15 years old (see Contraindications).
Discontinuation of treatment: Abrupt discontinuation of the treatment should be avoided. The dosage should be gradually reduced over a period of 7 to 14 days in order to reduce the risk of withdrawal reactions (see Precautions).
Method of administration: Oral route.