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Indications and Dosage
Oral
Depression Adult: 12.5 mg tid.
Elderly: Dose reduction to total daily dose of 25 mg. |
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Renal Impairment
Reduce total daily dose to 25 mg/day.
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Administration
Should be taken on an empty stomach. Take before main meals.
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Contraindications
Childn <15 yrs. Pregnancy and lactation.
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Special Precautions
General anaesthesia; tasks requiring mental alertness. Avoid abrupt withdrawal, dosage to be decreased gradually over 7-14 days.
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Adverse Reactions
Abdominal pain, fatigue, nausea, constipation, lack of appetite, insomnia, drowsiness, palpitations, muscular or joint pain, headache, vertigo, tremour, dry mouth, hepatitis (rare)
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Overdosage
Gastric lavage followed by symptomatic treatment and monitoring of CV, respiratory, metabolic and renal function.
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Drug Interactions
Potentially Fatal: Avoid concurrent admin with MAOI, start tianeptine 2 wk after discontinuation from MAOI.
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Food Interaction
Decreased absorption with alcohol.
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Action
Description:
Mechanism of Action: Tianeptine exerts its antidepressant action by increasing the presynaptic re-uptake of serotonin. |
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Storage
Store below 30°C.
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MIMS Class
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