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REPATHA is a sterile, preservative-free, clear to opalescent, colorless to pale yellow solution for subcutaneous use.
Evolocumab is a human monoclonal immunoglobulin G2 (IgG2) directed against human proprotein convertase subtilisin kexin 9 (PCSK9). Evolocumab has an approximate molecular weight (MW) of 144 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
Each single-use pre-filled autoinjector of REPATHA is designed to deliver 1 mL of 140 mg/mL solution.
Excipients/Inactive Ingredients: Each 1 mL single-use pre-filled autoinjector contains 140 mg evolocumab, acetate (1.2 mg), polysorbate 80 (0.1 mg), proline (25 mg) in Water for Injection, USP. Sodium hydroxide may be used to adjust to a pH of 5.0.
