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Symptoms of overdosage include fever, dizziness, bloating, numbness or muscle spasms in hands and feet, restlessness, increased heart rate, fatigue, confusion and headache.
In acute oral salicylate overdosage, repeated oral doses of activated charcoal be given if the patient is suspected of ingesting more than 125 mg/kg of salicylate within 1 hour of presentation. Intravenous sodium bicarbonate is given to enhance urinary salicylate excretion if plasma salicylate concentrations exceed 500 micrograms/ml. Haemodialysis or haemoperfusion should be seriously considered when the plasma salicylate concentration is more than 700 micrograms/ml.
