Increased plasma salicylate conc w/ dipyridamole, metoclopramide, metoprolol. Increased GI bleeding & ulceration w/ corticosteroids. Increased aspirin excretion w/ antacids. Increased activity of coumarin anticoagulants, sulfonylurea hypoglycaemics, zafirlukast, MTX, phenytoin, valproate. Diminished effects of uricosurics eg, probenecid, sulfinpyrazone. Increased risk of adverse effects w/ other NSAIDs. Abolished cardioprotective effects w/ ibuprofen or other NSAIDs. Decreased plasma conc of some other NSAIDs ie, fenbufen, indomethacin, piroxicam.