Recadin Mechanism of Action

RECADIN contains aspirin and glycine.
Aspirin reduces the stickiness of platelets, where formation of clot is less likely to be occurred in the blood vessels. Glycine helps to reduce gastric irritation caused by aspirin.
Pharmacology: Pharmacodynamics: Aspirin is a salicylate NSAID which inhibits platelet aggregation, in addition to its analgesic, anti-inflammatory, and antipyretic properties.
Glycine is a non-essential aliphatic amino acids. It is used in the aspirin preparation as to reduce gastric irritation.
Pharmacokinetics: Aspirin is absorbed rapidly from the gastrointestinal tract when taken orally. Once absorbed, aspirin is rapidly converted to salicylate, but during the first 20 minutes after an oral dose aspirin is the main form of the drug in the plasma. Aspirin is 80 to 90% bound to plasma proteins and is widely distributed; its volume of distribution is reported to be 170 mL/kg in adults. Both aspirin and salicylate have pharmacological activity although only aspirin has an anti-platelet effect. Salicylate is extensively bound to plasma proteins and is rapidly distributed to all body parts. Salicylate is mainly eliminated by hepatic metabolism; the metabolites include salicyluric acid, salicyl phenolic glucuronide, salicylic acyl glucuronide, gentisic acid, and gentisuric acid. Salicylate is also excreted unchanged in the urine; the amount excreted by this route increases with increasing dose and also depends on urinary pH, about 30% of a dose being excreted in alkaline urine compared with 2% of a dose in acidic urine.