Recadin Drug Interactions

Use of aspirin with dipyridamole may result in an increase in plasma-salicylate concentrations.
Drugs such as metoclopramide in patients with migraine headache result in earlier absorption of aspirin and higher peak plasma-salicylate concentrations. Metoprolol may also increase peak plasma-salicylate concentrations.
The use of corticosteroids increases the risk of gastrointestinal bleeding and ulceration associated with aspirin.
Antacids may increase the excretion of aspirin in alkaline urine.
Aspirin may increase the activity of coumarin anticoagulants, sulfonylurea hypoglycaemic drugs, zafirlukast, methotrexate, phenytoin, and valproate.
Aspirin diminishes the effects of uricosurics such as probenecid and sulfinpyrazone.
Use of aspirin with other NSAIDs should be avoided because of the increased risk of adverse effects.
The cardioprotective effects of aspirin may be abolished by ibuprofen and possibly other NSAIDs.
Aspirin may decrease the plasma concentration of some other NSAIDs, for example, fenbufen, indometacin, and piroxicam.