Sign Out
Use in Patients with Heart Failure: In a long-term placebo-controlled study (PRAISE-2) of amlodipine in patients with New York Heart Association (NYHA) class III and IV heart failure of non-ischemic etiology, amlodipine was associated with increased reports of pulmonary edema despite no significant differences in the incidence of worsening heart failure compared to placebo (see Pharmacology: Pharmacodynamics under Actions).
Effects on Ability to Drive and Use Machines: Clinical experience with amlodipine indicates that it is unlikely to impair a patient's ability to drive or use machinery.
Use in Patients with Impaired Hepatic Function: As with all calcium antagonists, amlodipine's half-life is prolonged in patients with impaired liver function and dosage recommendations have not been established in these patients. The drug should therefore be administered with caution in these patients.
