Norvasc Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amlodipine besilate

Indications/Uses

1st-line treatment of HTN & myocardial ischemia whether due to fixed obstruction (stable angina) &/or vasospasm/vasoconstriction (Prinzmetal's or variant angina) of coronary vasculature. Monotherapy or in combination w/ other antianginal drugs in patients w/ angina refractory to nitrates &/or β-blockers.

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Dosage/Direction for Use

HTN & angina Initially 5 mg once daily, may be increased to max: 10 mg. HTN Childn & adolescent 6-17 yr Initially 2.5 mg once daily, may be up-titrated to 5 mg once daily.

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Overdosage

View Norvasc overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to dihydropyridines.

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Special Precautions

NYHA class III & IV heart failure of non-ischaemic etiology. Hepatic impairment. Pregnancy & lactation. Childn <6 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headaches, dizziness, somnolence; palpitations; flushing; abdominal pain, nausea; oedema, fatigue.

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Drug Interactions

Increased exposure to simvastatin. Increased BP-lowering effects w/ grapefruit or grapefruit juice. Increased systemic exposure in elderly hypertensive patients w/ diltiazem. Increased plasma conc by strong CYP3A4 inhibitors eg, ketoconazole, itraconazole, ritonavir. Increased risk of hypotension w/ clarithromycin. Decreased plasma conc by CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Affected trough conc of cyclosporin. Increased tacrolimus blood levels. Increased exposure of mTOR inhibitors eg, sirolimus, temsirolimus, everolimus.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Norvasc detailed prescribing information

Storage

View Norvasc storage conditions for details to ensure optimal shelf-life.

Description

View Norvasc description for details of the chemical structure and excipients (inactive components).

Action

View Norvasc mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists / Anti-Anginal Drugs

ATC Classification

C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Norvasc tab 10 mg

Packing/Price

100's;30's

Form

Norvasc tab 5 mg

Packing/Price

100's;30's

Norvasc

amlodipine

Manufacturer:

Viatris

Distributor:

Zuellig Pharma