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Overdose has been reported in patients taking Ninlaro. Symptoms of overdose are generally consistent with the known risks of Ninlaro (see Adverse Reactions). Overdose of 12 mg (taken at one time) has resulted in serious adverse events, such as severe nausea, aspiration pneumonia, multiple organ failure and death. There is no known specific antidote for Ninlaro overdose. In the event of an overdose, monitor the patient closely for adverse reactions and provide appropriate supportive care. Ixazomib is not dialyzable (see Pharmacology: Pharmacokinetics under Actions).
Overdoses were most common in patients starting treatment with Ninlaro. The importance of carefully following all dosage instructions should be discussed with patients starting treatment. Instruct patients to take the recommended dosage as directed because overdose has led to deaths.
