Recommended initial dose: 4 mg once wkly on days 1, 8 & 15 of 28-day treatment cycle. Recommended initial lenalidomide dose: 25 mg daily on days 1-21 of 28-day treatment cycle. Recommended initial dexamethasone dose: 40 mg on days 1, 8, 15 & 22 of 28-day treatment cycle. Moderate hepatic, severe hepatic or renal impairment & ESRD requiring dialysis Reduce initial dose to 3 mg.
View Ninlaro overdosage for action to be taken in the event of an overdose.
Administration
Should be taken on an empty stomach: Take at approx the same day & time each week for the 1st 3 weeks, at least 1 hr before or 2 hr after meals. Swallow whole w/ water, do not crush/chew/open.
Thrombocytopenia; GI toxicities; peripheral edema; cutaneous reactions; thrombotic microangiopathy including TTP/hemolytic uremic syndrome. Monitor for symptoms of new or worsening peripheral neuropathy. Monitor platelet counts at least mthly during treatment & hepatic enzymes regularly. Hepatic or renal impairment. Men & women of childbearing potential should use effective contraception during & for 90 days following final dose. Avoid use during pregnancy. Not to be used during lactation & for 90 days after last dose. Ped patients.