Locoa Dosage/Direction for Use

Posology: LOCOA should be applied to the affected area once daily in adults. Do not use more than 2 patches at once.
Do not use more than 2 patches per day, since LOCOA is a topical patch with improved transdermal absorption and enhanced penetration of esflurbiprofen, the active ingredient, into the affected tissue. Also, the safety of LOCOA has been examined for up to 2 patches per day in clinical studies. The use of LOCOA with any other anti-inflammatory agent with expected systemic effects should be avoided wherever possible. If such use is deemed necessary, it should be limited to a minimal level and the condition of the patient should be carefully monitored.
Elderly: Since elderly patients are more susceptible to adverse reactions, their condition should be carefully monitored during treatment.
Paediatric population: Safety has not been established in low-birth-weight babies, neonates, nursing infants, infants and children. [Clinical studies have only been performed in adults and there is no experience in the use for the previously mentioned patients.]
Method of administration: LOCOA is administered topically by attaching the patch to the skin of the affected area.
LOCOA cannot be applied to the skin wounds, open injuries, mucous membrane or to the area of eczema or rash. If 2 patches are used at a time, the entire sticky side needs to be in direct contact with the skin. The patches should not be placed overlap or on top of another. LOCOA should be applied to clean and dry skin. Careful administration is required with attention to the skin condition of the application site. LOCOA should be detached slowly and carefully to prevent any damage to the skin.