Patients with peptic ulcer (See Precautions.)
Patients with severe blood abnormality.
Patients with severe liver disorder.
Patients with severe renal disorder.
Patients with severe cardiac dysfunction.
Patients with severe hypertension.
Patients with a history of hypersensitivity to the components of LOCOA or flurbiprofen.
Patients with current or previous aspirin-induced asthma (asthmatic attacks induced by nonsteroidal anti-inflammatory analgesics and other relevant drugs.)
Patients on enoxacin hydrate, lomefloxacin, norfloxacin, or prulifloxacin (See Interactions.)
Women in late pregnancy (See Use in Pregnancy & Lactation.)