Irinol Caution For Usage

Instructions for Use: As with other antineoplastic agents, IRINOL must be prepared and handled with caution. The use of glasses, mask and gloves is required.
If IRINOL solution or infusion solution should come into contact with the skin, wash immediately and thoroughly with soap and water. If IRINOL solution or infusion solution should come into contact with the mucous membranes, wash immediately with water.
Preparation for the intravenous infusion administration: As with any other injectable medicinal products, the IRINOL solution must be prepared aseptically.
If any precipitate is observed in the vials or after dilution, the product should be discarded according to standard procedures for cytotoxic agents.
Aseptically withdraw the required amount of IRINOL solution from the vial with a calibrated syringe and inject into a 250 ml infusion bag or bottle containing either 0.9% sodium chloride solution or 5% glucose solution. The infusion should then be thoroughly mixed by manual rotation.
The final concentration of Irinol (Irinotecan Concentrate for Solution for Infusion 20mg/ml) after dilution according to the above information is between 0.12 mg/ml to 3.0 mg/ml.
Incompatibilities: None known.
In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Disposal: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.