Common side effects include nausea, vomiting, diarrhea and abdominal pain. Larger doses may cause profuse diarrhea, gastrointestinal haemorrhage, muscle weakness, skin rashes, renal and hepatic damage. Dehydration and hypotension may follow. Alopecia, peripheral neuritis and bone marrow depression with agranulocytosis and aplastic anaemia may occur after prolonged treatment. Rarely, peripheral neuritis, myopathy, rhabdomyolysis may occur.