Overdosage may cause burning feeling in stomach, throat or skin; vomiting; convulsions; diarrhoea, fever, muscle weakness; pulmonary edema; respiratory depression or renal failure. Colchicine should be withdrawn or the dose reduced if adverse gastro-intestinal effects occur. For treatment in acute poisoning, the stomach should be emptied by aspiration and lavage. A purgative such as sodium sulphate 30 gm in 250 ml of water, should be given. Demulcent drinks may be given freely. Morphine sulphate, 10 mg, intramuscularly may be given to relieve abdominal cramps. Atropine has also been given.
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