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Overdose may precipitate hypoglycaemia due to the presence of the sulphonylurea (see Precautions).
High overdose or the existence of concomitant risk factors may lead to lactic acidosis due to the presence of metformin (see Precautions). Lactic acidosis is a medical emergency and must be treated in hospital. The most effective treatment is to remove lactate and metformin by haemodialysis.
The plasma clearance of glibenclamide may be prolonged in patients suffering from liver disease. Since glibenclamide is extensively bound to proteins, it is not eliminated by dialysis.
