This medicinal product must never be used in case of: hypersensitivity to metformin hydrochloride, glibenclamide or other sulphonylurea(s) and sulphonamide(s), or to any of the excipients; type 1 diabetes (insulin-dependent diabetes), diabetic pre-coma; Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis); Severe renal failure (GFR <30mL/min); acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock; disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as as cardiac or respiratory failure, recent myocardial infarction, shock; hepatic insufficiency, acute alcohol intoxication, alcoholism; porphyria; lactation; in association with miconazole (see Interactions).
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