Although frusemide is used in high doses for oliguria due to chronic or acute renal insufficiency it should not be given in anuria or in renal failure due to nephrotoxic or hepatotoxic drugs nor in renal failure associated with hepatic coma. Frusemide should not be given in pre-comatose states associated with hepatic cirrhosis. It should be used with care in patients with prostatic hypertrophy or impairment of micturition since it can precipitate acute urinary retention.
Use in Pregnancy: Frusemide should be used with caution in pregnancy.
Use in Lactation: Frusemide passes into breast milk, and inhibit lactation. Therefore, it must not be given during breast feeding.