Fusix Adverse Reactions

The most common side-effect associated with frusemide therapy is fluid and electrolyte imbalance including hyponatraemia, hypokalaemia, and hypochloraemic alkalosis, particularly after large doses or prolonged administration. Unlike the thiazide diuretics, it increases the urinary excretion of calcium.
Nephrocalcinosis has been reported when frusemide has been used to treat preterm infants. Frusemide may provoke hyperglycaemia and glycosuria, but probably to a lesser extent than the thiazide diuretics. It may cause hyperuricaemia and precipitate attacks of gout in some patients.
Diuresis (strong): The most commonly encountered adverse effects attributable to frusemide are fluid depletion and electrolyte disturbance arising from frusemide's diuretic actions.
Levels of serum lipids: Most studies into the effects of diuretics on bloods-lipids concentrations have used thiazides and long-term studies have suggested that adverse effects on blood lipids may be transitory, although the complete lipid-lipoprotein analysis necessary for full evaluation of the effects has generally not been performed. The few studies into the effects of frusemide suggest that it may adversely influence blood-lipid concentrations during short-term administration.
Adverse dermatologic and/or hypersensitivity reactions to frusemide include purpura, photosensitivity, rash, urticaria, pruritus, exfoliative dermatitis, erythema multiforme, and necrotizing angiitis (vasculitis, cutaneous vasculitis). Patients with known sulfonamide sensitivity may show allergic reactions to frusemide. Anaphylaxis, manifested as urticaria, angioedema, and hypotension, occurred with 5 minutes after IV administration of frusemide in at least one patient; subsequent intradermal skin testing showed sensitivity to frusemide and other sulfonamides.