Frusemide is contraindicated in patients with anuria. The drug contraindicated for further use if increasing azotemia and/or oliguria occur during the treatment of severe, progressive renal disease. In patients with hepatic coma or electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Frusemide is also contraindicated in patients with a history of hypersensitivity to the drug and to sulphonamides.
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