Fluimucil Drug Interactions

Effervescent tab/Powd for oral soln: There are no in vivo interaction studies.
The co-administration of activated charcoal in case of intoxication may reduce the effect of acetylcysteine administered gastrointestinally.
So far, the reports mentioning an inactivation of antibiotics by acetylcysteine relate exclusively to in-vitro tests in which the substances concerned had been directly mixed. Nevertheless, for safety reasons, the oral administration of antibiotics should be done separately within an interval of at least two hours.
In case of a simultaneous administration of glyceryl trinitrate, the vasodilatory and the inhibiting thrombocytes aggregation effects may be enhanced.
The co-administration of acetylcysteine and carbamazepine may result in subtherapeutic carbamazepine concentrations.
Simultaneous administration of an antitussive: see "Precautions".
Syrup: Mucolytics such as acetylcysteine should not be administered concomitantly with antitussive medicinal products, because a reduction in the cough reflex could cause an accumulation of bronchial secretions.
Activated charcoal can decrease the effect of acetylcysteine.
Simultaneous dissolution of acetylcysteine formulations with other medicinal products is not recommended.
To date, the inactivation of antibiotics by acetylcysteine has been reported only in in vitro tests, whereby the relevant substances were mixed directly with each other. However, if oral antibiotics or other medicinal products are required, it is advised that these should be taken 2 hours before or after acetylcysteine. This does not apply to loracarbef.
It has been shown that the concomitant use of nitrate derivatives and acetylcysteine can cause severe hypotension and an increase in vasodilation of the temporal artery. If concomitant administration of a nitrate derivative and acetylcysteine is necessary, patients must be monitored to detect any hypotension, which could potentially be severe. They must also be warned that they may develop headaches.
The concomitant use of acetylcysteine and carbamazepine can result in sub-therapeutic carbamazepine concentrations.
Paediatric population: Interaction studies have only been conducted in adults.
Laboratory test changes: N-acetylcysteine may interfere with the colorimetric analysis method used to assay salicylates.
N-acetylcysteine may interfere with assay of ketonuria.