Sign Out
Use during pregnancy: Pregnancy categories C. There are no adequate and well-controlled studies in pregnant women. There have been reports of multiple congenital abnormalities, in infants whose mothers were being treated for three or more months with high dose (400-800 mg/day) fluconazole therapy for coccidioidomycosis. The relationship between fluconazole and these events is unclear. Accordingly, use in pregnancy should be avoided, except in patients with severe or potentially life-threatening fungal infections, in whom fluconazole may be used if the anticipated benefit outweighs the possible risk to the foetus. Fluconazole should not be used in women of childbearing potential, unless adequate contraception is employed.
Use during lactation: Fluconazole is found in human breast milk at concentrations similar to plasma, hence its use in nursing mothers is not recommended.
