Cryptococcal meningitis & cryptococcal infections at other sites 400 mg on 1st day followed by 200-400 mg once daily for at least 6-8 wk. Candidemia, disseminated candidiasis, other invasive candidal infections 400 mg on 1st day followed by 200 mg daily, may be increased to 400 mg daily. Oropharyngeal candidiasis 50-100 mg once daily for 7-14 days. Atrophic oral candidiasis associated w/ dentures 50 mg once daily for 14 days concurrently w/ local antiseptic. Other candidal mucosal infections (except genital candidiasis) 50-100 mg daily for 14-30 days. ChildnMucosal candidiasis Loading dose: 6 mg/kg on 1st day followed by 3 mg/kg daily. Systemic candidiasis & cryptococcal infections 6-12 mg/kg daily.
Anaphylaxis. Discontinue use if signs or symptoms of liver disease develop. AIDS patients, SJS & TEN, QT interval prolongation, Torsade de pointes, structural heart disease, electrolyte abnormalities. Potentially proarrhythmic conditions. Concomitant use w/ terfenadine. Renal impairment. Not to be used in women of childbearing potential, pregnancy & lactation.
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