Factive Drug Interactions

Antacids/Di- and Trivalent Cations: The absorption of oral gemifloxacin is significantly reduced and its efficacy may be lowered when aluminium- and/or magnesium containing antacids, ferrous sulfate (iron), multivitamin preparations containing zinc or other metal cations (e.g., iron and calcium) are concomitantly administered. FACTIVE should not be taken within three hours before or two hours after taking these agents.
Didanosine: FACTIVE should not be taken within three hours before or two hours after taking didanosine.
Sucralfate: The oral bioavailability of gemifloxacin is significantly reduced when sucralfate is administered three hours prior to gemifloxacin. FACTIVE should be taken at least two hours before sucralfate.
Warfarin: FACTIVE had no significant effect on the anticoagulant effect of warfarin in healthy subjects on stable warfarin therapy. However, increases in the INR (International Normalized Ratio), or PT (prothrombin time), and/or clinical episodes of bleeding in patients have been noted with the use of quinolones, including FACTIVE, and warfarin, or its derivatives. The PT, INR, or other suitable coagulation test should be closely monitored if a quinolone antimicrobial including FACTIVE is administered concomitantly with warfarin or its derivatives.
Probenecid: Concomitant administration of FACTIVE with probenecid resulted in the systemic exposure to gemifloxacin and reduction in the mean renal clearance of gemifloxacin.
No clinically significant interactions have been observed when gemifloxacin was coadministered with omeprazole, theophylline, digoxin, oral contraceptives, or cimetidine.